Monday, January 28, 2019

Journal of Biomedical Engineering and Bioscience - Lupine Publishers-


In order to interpret the vast amount of information available on sequencing the genetic composition of patients, the data on analyzing diseases, genetic mutations, cellular reactions with genes, interactomes, medications, drug reactions and toxicities, doses of drugs and therapeutic schedules, and epidemiology problems, it is necessary to have secure methods with which to work. Reference is made to an earlier discussion on the use of computational mathematics and mathematical models for understanding personalized medicine. Kushner [1]. This article seeks to explain the benefits of yet another method available to decipher the vast amount of data that is being generated. Recently there has been a tremendous amount of discussion and publicity about crypto currency and blockchain technology among public and financial institutions. Most of this has been centered on financial transfers using Bit coin and other crypto currency avenues. - Lupine Publishers.



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Monday, January 14, 2019

Binding Model of Antidiabetic Constituents from Capsosiphon fulvescens with Human Aldose Reductase: OAJBEB - Lupine Publishers

Binding Model of Antidiabetic Constituents from  Capsosiphon fulvescens  with Human Aldose Reductase by Ogunwa Tomisin Happy in Open Access Journal of Biomedical Engineering and Biosciences (OAJBEB) - Lupine Publishers

The use of seaweeds as functional foods and drugs is well known. Capsosiphon fulvescens (C. fulvescens) is a green sea alga for which beneficial health impacts have been reported even in diabetes. In the present study, three C. fulvescens constituents (chalinasterol, capsofulvesin A and capsofulvesin B) were evaluated for their molecular binding signature and interaction patterns against human aldose reductase as an antidiabetic target. The enzyme has been robustly implicated in the development of secondary complications of diabetes. The results generated here with the aid of in silico tools revealed a favourable binding affinity for the seawed constituents on the active site of aldose reductase. However, detailed observation shows no interference with the NADP binding pocket. The binding configuration of capsofulvesin A and capsofulvesin B were comparable to fidarestatas the compounds inserted one of their elongated aliphatic long chains with double bonds into the binding pocket. Nonetheless, subtle differences were sighted with the binding format of the aliphatic chain of capsofulvesin B resulting from a possible hydrophobic hinderance or influence within the binding pocket. Only one of the aliphatic chains of capsofulvesin A enjoyed hydrophobic interaction with residues Val47, Trp219 and Phe122 compared to the capsofulvesin B having hydrophobic interaction with Phe122 at the second chain while the other aliphatic chain formed hydrophobic bond with Trp20, Val47, Trp219 and Leu300. Meanwhile, the galactose unit of the two compounds displayed similar binding orientation and interaction with amino acid residues Ser22 and Trp20 at the active site. Chalinasterol, on the other hand, established hydrogen bond with the imidazole ring of His110 and indole ring of Trp111 respectively. The current study represents the first attempt to model the interaction of these ligands with aldose reductase and the unique binding patterns might explain the mechanism and potency of C. fulvescens in the management of diabetes and its complications - Lupine Publishers.

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Monday, January 7, 2019

Study About the Despeckling Methods for Retinal Optical Coherence Tomography Images: (OAJBEB)- Lupinepublishers





This paper presents study about the different despeckling methods used for quality enhancement of retinal optical coherence tomography (OCT) images. Speckle noise is an inherent property of an OCT images which affects the visual quality of the images, hence difficult to diagnosis the patients. Therefore speckle noise reduction from the OCT images is an important prerequisite, whenever OCT imaging is used for diagnosis. The speckle noise intensity depends on the various imaging system parameters of its systems and the different structure representations used for the image tissues. A despeckling technique is to be designed in such a way that it should be able to reduce the speckle noise from the OCT images while preserving the tissues and fine details of the images Lupine publishers.

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Lupine Publishers | The Possibility of Complex Treatment of Optic Nerve Atrophy based on Etiopathogenetic Approach using the New Classification of this Ophthalmopathology

Lupine Publishers | Open Access Journal of Biomedical Engineering and Biosciences Abstract Application of treatment, different...